CAS RN 878739-06-1

IUPAC Name: 3-(1-cyano-1-methylethyl)-N-{4-methyl-3-[(3-methyl-4-oxo-3,4-dihydroquinazolin-6-yl)amino]phenyl}benzamide

Synonyms: 3-(1-cyano-1-methylethyl)-N-{4-methyl-3-[(3-methyl-4-oxoquinazolin-6-yl)amino]phenyl}benzamide

Molecular Weight (g/mol): 451.53

Molecular Formula: C27H25N5O2

InChi Key: ZGBGPEDJXCYQPH-UHFFFAOYSA-N

SMILES: CN1C=NC2=CC=C(NC3=C(C)C=CC(NC(=O)C4=CC(=CC=C4)C(C)(C)C#N)=C3)C=C2C1=O

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CAS: 878739-06-1 Molecular Formula: C27H25N5O2

CAS	878739-06-1
Molecular Formula	C27H25N5O2

MEK/ERK pathway inhibitor; Inhibits B-RAF, B-RAFV600E, and C-RAF-1

MedChemExpress AZ 628 is a pan-Raf kinase inhibitor with IC50s of 105, 34 and 29 nM for B-Raf, B-RafV600E, and c-Raf-1, respectively.

Molecular Weight (g/mol)	451.52
Color	Pink
Physical Form	Solid
Chemical Name or Material	AZ 628
Grade	Research
SMILES	O=C1N(C)C=NC2=C1C=C(C=C2)NC3=C(C)C=CC(NC(C4=CC(C(C#N)(C)C)=CC=C4)=O)=C3
For Use With (Application)	Cancer-Kinase/protease
Percent Purity	99.86%
CAS	878739-06-1
Solubility Information	DMSO : ≥ 50 mg/mL (110.74 mM)
Health Hazard 1	H301∣H315∣H319∣H335
Purity Grade Notes	Research
Recommended Storage	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Shelf Life	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molecular Formula	C₂₇H₂₅N₅O₂
Formula Weight	451.52