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2,2,2-Trifluoroethanol, 99+%, Thermo Scientific Chemicals
Description
Trifluoroethanol serves as a solvent and a raw material in organic chemistry and biology. TFE is a solvent of choice for hydrogen peroxide-mediated oxidations of sulfides. Trifluoroethanol acts as a protein denaturant. It is used in the manufacture of certain pharmaceuticals and drug substances. The drug fluromer, which is 2,2,2-trifluoro-1-vinyloxyethane, is the vinyl ether of trifluorethanol. It is an effective solvent for peptides and proteins, and used for NMR-based protein folding studies, and in the manufacture of nylon. As a source of the trifluoromethyl group, it is employed in several organic reactions, for example in Still-Gennari modification of Horner-Wadsworth-Emmons reaction (HWE) reaction.
This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
Trifluoroethanol serves as a solvent and a raw material in organic chemistry and biology. TFE is a solvent of choice for hydrogen peroxide-mediated oxidations of sulfides. Trifluoroethanol acts as a protein denaturant. It is used in the manufacture of certain pharmaceuticals and drug substances. The drug fluromer, which is 2,2,2-trifluoro-1-vinyloxyethane, is the vinyl ether of trifluorethanol. It is an effective solvent for peptides and proteins, and used for NMR-based protein folding studies, and in the manufacture of nylon. As a source of the trifluoromethyl group, it is employed in several organic reactions, for example in Still-Gennari modification of Horner-Wadsworth-Emmons reaction (HWE) reaction.
Solubility
Miscible with water, ethers, ketones, alcohols and chloroform.
Notes
Moisture sensitive.
Specifications
| Melting Point | -44°C |
| Density | 1.391 |
| Boiling Point | 74°C to 75°C |
| Flash Point | 29°C (84°F) |
| Linear Formula | CF3CH2OH |
| Refractive Index | 1.29 |
| Quantity | 500 g |
| UN Number | UN1992 |
| Beilstein | 1733203 |
| Solubility Information | Miscible with water,ethers,ketones,alcohols and chloroform. |
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Safety and Handling
- 2,2,2-Trifluoroethanol
- Danger
- Acute toxicity Category 3
- Serious eye damage/eye irritation Category 1
- Flammable liquid Category 3
- Reproductive toxicity Category 1B
- Specific target organ toxicity after repeated exposure Category 2
- H226-Flammable liquid and vapour.
- H301-Toxic if swallowed.
- H318-Causes serious eye damage.
- H331-Toxic if inhaled.
- H360F-May damage fertility.
- H373-May cause damage to organs.
- P210-Keep away from heat, hot surfaces, sparks, open flames and other ignition sources. No smoking.
- P280-Wear protective gloves/protective clothing/eye protection/face protection.
- P302+P352-IF ON SKIN: Wash with plenty of water/soap.
- P304+P340-IF INHALED: Remove person to fresh air and keep comfortable for breathing.
- P305+P351+P338-IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
- P310-Immediately call a POISON CENTER/doctor/.
- MIXTURE LIST-Contains : 2,2,2-Trifluoroethanol
RUO – Research Use Only