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2'-Fluoro-iBu-G Phosphoramidite, standard grade, 20-400 finish bottle

Product Code. 30054432 Shop All Thermo Scientific Products
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Quantity:
0.25 g
Unit Size:
0.25g
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Product Code. 30054432

Brand: Thermo Scientific 27160709

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Description

2'-Fluoro-iBu-G CEP is a phosphoramidite containing 5' DMT and the nucleoside guanosine (G) with 2'-Fluoro protection, for use in oligonucleotide synthesis.

Located in the ideal oligo position, the highly electronegative fluorine (2'-Fluoro) modification adopts a more thermodynamically stable A-form helix on hybridization to its target. Showing improved affinity and some nuclease resistance (compared to 2'-OH), the 2'-F modification has been proven useful in antisense, siRNA, and aptamer applications. The 'standard grade' marking denotes a baseline level of purity verified with analytical methods, and proven to be suitable for most oligo synthesis requirements. This product is supplied in a 30-mL amber bottle with a 20-400 finish neck style, which is compatible with most Expedite synthesizers.

Features:

  • Full chemical name—5'-O-(4,4'-Dimethoxytrityl)-N2-isobutyryl-2'-fluoroguanosine-3'-O-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite
  • Molecular formula—C44H53FN7O8P
  • Base—G
  • Base Protection—iBu
  • Formula weight—857.4 g/mol
  • CAS number—144089-97-4
  • HPLC purity—>98%
  • 31P NMR purity—≥98%
TRUSTED_SUSTAINABILITY

Specifications

Format Powder
For Use With (Equipment) Expedite Synthesizers
Product Type 2in-Fluoro-iBu-G CEP
Content And Storage Store in freezer (at or below -20°C).
Nucleoside Type Guanosine (G)
Reagent Features 2in-Fluoro modified
Shipping Condition Room Temperature
Purity 98%
Quantity 0.25 g
Reagent Type Phosphoramidite
Grade Standard
Nucleic Acid Type RNA
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For Research Use Only. Not for use in diagnostic procedures.

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