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Invitrogen™ 4E-BP2 Polyclonal Antibody

Product Code. 15755831 Shop All Thermo Scientific Products
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Quantity:
100 μL
Unit Size:
100µL
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15755831 100 μL 100µL
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Product Code. 15755831 Supplier Invitrogen™ Supplier No. PA557941

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Description

Rabbit Polyclonal Antibody

Immunogen sequence: VTSPGTLIED SKVEVNNLNN LNNHDRKHAV GDDAQ Highest antigen sequence identity to the following orthologs: Mouse - 94%, Rat - 91%.

PHAS-II (eIF4E-binding protein II) is involved in translation initiation. PHAS-II is highest in liver and kidney. PHAS proteins bind to eIF-4E, the mRNA cap-binding protein, and inhibit translation of capped mRNA in vitro and in cells. Phosphorylation in the appropriate site(s) promotes dissociation of PHAS/eIF-4E complexes. This allows eIF-4E to bind to eIF-4G (p220), thereby increasing the amount of the eIF-4F complex and the rate of translation initiation. Pharmacological and genetic evidence indicates that the mTOR/p70S6K pathway is involved in the control of PHAS-I and -II. Thus, PHAS proteins may be mediators of the effects of this pathway on protein synthesis and cell proliferation.
TRUSTED_SUSTAINABILITY

Specifications

Antigen 4E-BP2
Applications Immunohistochemistry (Paraffin)
Classification Polyclonal
Concentration 0.4 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene EIF4EBP2
Gene Accession No. Q13542
Gene Alias 2810011I19Rik; 4EBP2; 4E-BP2; AA792569; BC010348; eIF4E-binding protein 2; EIF4EBP2; eukaryotic translation initiation factor 4E binding protein 2; eukaryotic translation initiation factor 4E-binding protein 2; PHASII; PHAS-II; Phosphorylated heat- and acid-stable protein regulated by insulin 2; phosphorylated, heat and acid stable regulated by insulin protein II
Gene Symbols EIF4EBP2
Host Species Rabbit
Immunogen Recombinant protein corresponding to Human 4E-BP2. Recombinant protein control fragment (Product #RP-102764).
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 1979
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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