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Invitrogen™ 5-Methylcytosine Polyclonal Antibody
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Product Code. 16312455
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Quantity:
100 μL
Unit Size:
100µL
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Product Code. Quantity unitSize
16312455 100 μL 100µL
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Product Code. 16312455 Supplier Invitrogen™ Supplier No. PA585516

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Description

Rabbit Polyclonal Antibody

Keep as concentrated solution. Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Methylation of DNA cytosine bases plays important roles in the regulation of gene transcription. It has been estimated that 60 to 90% of the cytosines in CpG dinucleotides are methylated. An increase in methyl-CpG correlates with transcriptional silencing for the whole chromosome especially in developmentally regulated genes. Methylation is believed to lead to transcriptional silencing by multiple mechanisms including alteration of transcription factor binding to promoters and alteration in chromatin structure.
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Specifications

Antigen 5-Methylcytosine
Applications Dot Blot, Immunomicroscopy, Methylated DNA Immunoprecipitation
Classification Polyclonal
Concentration 7.55 mg/mL
Conjugate Unconjugated
Formulation PBS with 20% glycerol and 0.025% ProClin 300; pH 7
Gene Alias 5mc; 5-mC; 5-meC; 5-Methyl-cytosine; C5H7NO3
Host Species Rabbit
Immunogen 5-MethylCytosine/5-mC.
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Target Species Chemical
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
Target Molecule Chemical
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