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Invitrogen™ 53BP2 Polyclonal Antibody
Rabbit Polyclonal Antibody
Brand: Invitrogen™ PA5105248
This item is not returnable.
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Description
Antibody detects endogenous levels of total ASPP2.
Regulator that plays a central role in regulation of apoptosis and cell growth via its interactions. Regulates TP53 by enhancing the DNA binding and transactivation function of TP53 on the promoters of proapoptotic genes in vivo. Inhibits the ability of APPBP1 to conjugate NEDD8 to CUL1, and thereby decreases APPBP1 ability to induce apoptosis. Impedes cell cycle progression at G2/M. Its apoptosis-stimulating activity is inhibited by its interaction with DDX42.
Specifications
| 53BP2 | |
| Polyclonal | |
| Unconjugated | |
| TP53BP2 | |
| 53BP2; Apoptosis-stimulating of p53 protein 2; apoptosis-stimulating protein of p53, 2; ASPP2; BBP; Bcl2-binding protein; P PPP1R13A; P53BP2; PPP1R13A; Renal carcinoma antigen NY-REN-51; TP53BP2; transformation related protein 53 binding protein 2; Trp53bp2; tumor protein p53 binding protein 2; tumor protein p53 binding protein, 2; tumor suppressor p53-binding protein 2 | |
| Rabbit | |
| Affinity chromatography | |
| RUO | |
| 305025, 7159 | |
| -20°C | |
| Liquid |
| Western Blot | |
| 1 mg/mL | |
| PBS with 50% glycerol and 0.02% sodium azide; pH 7.4 | |
| Q13625 | |
| TP53BP2 | |
| A synthesized peptide derived from human TP53BP2(Accession Q13625), corresponding to amino acid residues G672-R722. | |
| 100 μL | |
| Primary | |
| Human, Mouse, Rat | |
| Antibody | |
| IgG |
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