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ABCB1 Mouse anti-Human, Clone: OTI6H2, lyophilized, TrueMAB™

Product Code. 17676401
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Quantity:
100 μg
Unit Size:
100µg
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17676401 100 μg 100µg
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Product Code. 17676401 Supplier Origene Technologies Supplier No. CF801007

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Description

Mouse Monoclonal Antibody

Reconstitute with PBS (pH 7.3) and recommend to perform another round of desalting process using Product No. 7KMWCO

The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is an ATP-dependent drug efflux pump for xenobiotic compounds with broad substrate specificity. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs. This protein also functions as a transporter in the blood-brain barrier.

Specifications

Antigen ABCB1
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Monoclonal
Clone OTI6H2
Conjugate Unconjugated
Formulation PBS with 8% trehalose and no preservative; pH 7.3
Gene ABCB1
Gene Accession No. P08183
Gene Alias ABC20, CD243, CLCS, GP170, MDR1, P-GP, PGY1
Gene Symbols ABCB1
Host Species Mouse
Immunogen Human recombit protein fragment corresponding to amino acids 995-1280 of human ABCB1 produced in SF9 cell.
Purification Method Affinity Chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 5243
Target Species Human
Content And Storage -20° C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Lyophilized
Isotype IgG2a
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