Invitrogen™ ABHD8 Polyclonal Antibody

Description

Immunogen sequence: LGYEVVAPDL AGHGASSAPQ VAAAYTFYAL AEDMRAIFKR YAKKRNVLIG HSYGVSFCTF LAHEYPDLVH KVIMINGGGP TALEPSFCSI Highest antigen sequence indentity to the following orthologs: Mouse - 98%, Rat - 98%.

The alpha/beta hydrolase superfamily comprise diverse members that are involved in important biochemical processes and related to various diseases. They have unrelated sequences, various substrates, and different kinds of catalytic activities, yet they share the same canonical alpha/beta hydrolase fold, which consists of an eight-stranded parallel alpha/beta structure. They are also characterized by a catalytic triad composed of a histidine, an acid and a nucleophile. Members of this superfamily are often drug targets for treating diseases, such as diabetes, Alzheimer's disease, obesity and blood clotting disorders. The alpha/beta hydrolase domain containing (ABHD) gene subfamily is comprised of 15 mostly uncharacterized members, most of which utilize a serine nucleophile to form the G-X-S-X-G nucleophile elbow. ABHD8 is a 439 amino acid protein that belongs to the AB hydrolase superfamily.