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Invitrogen™ ACAP2 Polyclonal Antibody
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Product Code. 16536631
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Quantity:
100 μL
Unit Size:
100µL
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16536631 100 μL 100µL
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Product Code. 16536631 Supplier Invitrogen™ Supplier No. PA588364

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Description

Rabbit Polyclonal Antibody

Immunogen sequence: KAFCVANKQF MNGIRDLAQY SSNDAVVETS LTKFSDSLQE MINFHTILFD QTQRSIKAQL QNFVKEDLRK FKDAKKQFEK VSEEKENALV KNAQVQRNKQ HEVEEATNIL T; Positive Samples: LO2, HeLa, Jurkat, U-87MG, A-549, Mouse brain, Mouse liver; Cellular Location: Endosome membrane, Peripheral membrane protein.

ACAP2 is a transport carrier belonging to the Centaurin family with three ANK repeats, an Arf-GAP domain, a BAR domain, and a PH domain. ACAP2, a GTPase-activating protein (GAP) for ADP ribosylation factor 6 (ARF6) has robust constitutive ARF6 GAP activity, where the GAP activity is stimulated by phosphatidylinositol 4,5-bisphosphate (PIP2) and phosphatidic acid but has little activity toward ARF1 and is known to control the return of ARF to the inactive GDB-bound shots. ACAP2, along with ACAP1, is targeted by phosphatidyl inositol (3, 4, 3) triphosphate inhibiting the formation of PDGF-induced dorsal membrane ruffles in NIH3T3 fibroblasts when overexpressed. ACAP2 is phosphorylated upon DNA damage, probably by ATM or ATR. Expression is wide-spread with the highest level in lung.
TRUSTED_SUSTAINABILITY

Specifications

Antigen ACAP2
Applications ELISA, Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1.22 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.01% thimerosal; pH 7.3
Gene ACAP2
Gene Accession No. Q15057, Q6ZQK5
Gene Alias 4832442G16; 9530039J15Rik; ACAP2; Arf GAP with coiled coil, ANK repeat and PH domains 2; arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2; ArfGAP with coiled-coil, ankyrin repeat and PH domains 2; centaurin beta2; centaurin, beta 2; centaurin-beta-2; Centb2; CNT-B2; KIAA0041; mKIAA0041
Gene Symbols ACAP2
Host Species Rabbit
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 50-160 of human ACAP2 (NP_0364193).
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 23527, 78618
Target Species Human, Mouse
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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