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Invitrogen™ ACAP2 Polyclonal Antibody
Rabbit Polyclonal Antibody
Brand: Invitrogen™ PA5114808
This item is not returnable.
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Description
Antibody detects endogenous levels of total ACAP2.
ACAP2 is a transport carrier belonging to the Centaurin family with three ANK repeats, an Arf-GAP domain, a BAR domain, and a PH domain. ACAP2, a GTPase-activating protein (GAP) for ADP ribosylation factor 6 (ARF6) has robust constitutive ARF6 GAP activity, where the GAP activity is stimulated by phosphatidylinositol 4,5-bisphosphate (PIP2) and phosphatidic acid but has little activity toward ARF1 and is known to control the return of ARF to the inactive GDB-bound shots. ACAP2, along with ACAP1, is targeted by phosphatidyl inositol (3, 4, 3) triphosphate inhibiting the formation of PDGF-induced dorsal membrane ruffles in NIH3T3 fibroblasts when overexpressed. ACAP2 is phosphorylated upon DNA damage, probably by ATM or ATR. Expression is wide-spread with the highest level in lung.
Specifications
| ACAP2 | |
| Polyclonal | |
| Unconjugated | |
| ACAP2 | |
| 4832442G16; 9530039J15Rik; ACAP2; Arf GAP with coiled coil, ANK repeat and PH domains 2; arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2; ArfGAP with coiled-coil, ankyrin repeat and PH domains 2; centaurin beta2; centaurin, beta 2; centaurin-beta-2; Centb2; CNT-B2; KIAA0041; mKIAA0041 | |
| Rabbit | |
| Affinity chromatography | |
| RUO | |
| 23527, 619382, 78618 | |
| -20°C | |
| Liquid |
| Western Blot, Immunocytochemistry | |
| 1 mg/mL | |
| PBS with 50% glycerol and 0.02% sodium azide | |
| Q15057, Q5FVC7, Q6ZQK5 | |
| ACAP2 | |
| A synthesized peptide derived from human ACAP2(Accession Q15057), corresponding to amino acid residues G746-F778. | |
| 100 μL | |
| Primary | |
| Human, Mouse, Monkey, Rat | |
| Antibody | |
| IgG |
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