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Invitrogen™ ADAM10 Polyclonal Antibody
Rabbit Polyclonal Antibody
Brand: Invitrogen™ PA519898
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Description
In Western blot applications, this antibody detects a band at ~85kDa, which may represent precursor. A suggested positive control is Jurkat cell lysate. PA5-19898 can be used with blocking peptide PEP-0024.
Proinflammatory cytokine tumor necrosis factor-a (TNF-a) contributes to a variety of inflammatory responses and programmed cell death. Notch receptor and its ligand participate in cell fate decisions during vertebrate development and are associated with several human disorders, including a T-cell lymphoma. TNF-a, notch and its ligand delta are all membrane-bond molecules, which are cleaved by proteases to release mature proteins or functional receptor. ADAM10, a metalloprotease-disintegrin in the family of mammalian ADAM (for a disintegrin and metalloprotease), was recently identified to cleave TNF-a, notch and its ligand delta (1-3). The genes encoding human, mouse, and bovine ADAM10 were recently cloned and designated ADAM 10, kuzbanian (KUZ), and MADM, respectively. ADAM10 mRNA is expressed in a variety of human and bovine tissues.
Specifications
| ADAM10 | |
| Polyclonal | |
| Unconjugated | |
| Adam10 | |
| 1700031C13Rik; a disintegrin and metallopeptidase domain 10; a disintegrin and metalloprotease domain (ADAM) 10; a disintegrin and metalloprotease domain 10; a disintegrin and metalloproteinase; AD10; AD18; ADAM; ADAM 10; ADAM metallopeptidase domain 10; ADAM10; ADAMs; CD156c; CDw156; Disintegrin and metalloproteinase domain-containing protein 10; HsT18717; KUZ; kuzbanian; kuzbanian protein homolog; MADM; Mammalian disintegrin-metalloprotease; metalloendopeptidases; metalloproteinase; myelin-associated metalloproteinase; RAK | |
| Rabbit | |
| Antigen Affinity Chromatography | |
| RUO | |
| 102 | |
| Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C | |
| Liquid |
| Western Blot, Immunocytochemistry | |
| 1 mg/mL | |
| PBS with 0.02% sodium azide | |
| O14672 | |
| Adam10 | |
| A peptide corresponding to amino acids 732 to 748 of human ADAM10. | |
| 100 μg | |
| Primary | |
| Human | |
| Antibody | |
| IgG |
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