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Invitrogen™ ADAP Polyclonal Antibody
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Product Code. 16339894
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Quantity:
100 μL
Unit Size:
100µL
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16339894 100 μL 100µL
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Product Code. 16339894 Supplier Invitrogen™ Supplier No. PA582934

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Description

Rabbit Polyclonal Antibody

Immunogen sequence: RPFRVTGPNS SSGIQARKNL FNNQGNASPP AGPSNVPKFG SPKPPVAVKP SSEEKPDKEP KPPFLKPTGA GQRFGTPASL TTRDPEAKVG FLKPVGPKPI NLPKEDSKPT FPWPPGNKPS LHSVNQD Highest antigen sequence indentity to the following orthologs: Rat - 69%, Mouse - 69%.

The adhesion and degranulation adaptor protein (ADAP) was initially identified as a molecular adapter that couples T cell receptor (TCR) stimulation to the avidity of integrins governing T cell adhesion. TCR stimulation promotes the formation of a multi-protein complex containing CARMA1, MALT1, and BCL-10, which through the association of ADAP, ultimately activates the NF-kappa-B family of transcription factors. More recent experiments have shown that ADAP controls optimal T cell proliferation, cytokine production, and expression of the Bcl-2 family member Bcl-x(L), suggesting that ADAP regulates T cell activation by promoting antigen-dependent T cell-antigen presenting cell (APC) activation. At least three isoforms of ADAP are known to exist.
TRUSTED_SUSTAINABILITY

Specifications

Antigen ADAP
Applications Immunohistochemistry (Paraffin)
Classification Polyclonal
Concentration 0.2 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene FYB1
Gene Accession No. O15117
Gene Alias ADAP; adhesion and degranulation promoting adaptor protein; adhesion and degranulation-promoting adaptor protein; B630013F22Rik; Fyb; Fyb1; FYB-120/130; FYN binding protein; FYN binding protein (FYB-120/130); FYN binding protein FYB-130; FYN-binding protein; FYN-binding protein 1; FYN-T-binding protein; p120/130; p120/p130; PRO0823; RGD1563421; Slap130; SLAP-130; SLP-76-associated phosphoprotein
Gene Symbols FYB1
Host Species Rabbit
Immunogen Recombinant protein corresponding to Human FYB1. Recombinant protein control fragment (Product #RP-102114).
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 2533
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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