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  8. Adezmapimod hydrochloride, MedChemExpress

Adezmapimod hydrochloride, MedChemExpress

Product Code. 16484806
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Product Code. 16484806 Supplier Medchem Express Supplier No. HY10256A

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Description

MedChemExpress Adezmapimod (SB 203580) hydrochloride is a selective and ATP-competitive p38 MAPK inhibitor with IC50s of 50 nM and 500 nM for SAPK2a/p38 and SAPK2b/p38β2, respectively. Adezmapimod hydrochloride inhibits LCK, GSK3β and PKBα with IC50s of 100-500-fold higher than that for SAPK2a/p38. Adezmapimod hydrochloride is an autophagy and mitophagy activator.

Adezmapimod (SB 203580) hydrochloride is a selective and ATP-competitive p38 MAPK inhibitor with IC50s of 50 nM and 500 nM for SAPK2a/p38 and SAPK2b/p38β2, respectively. Adezmapimod hydrochloride inhibits LCK, GSK3β and PKBα with IC50s of 100-500-fold higher than that for SAPK2a/p38. Adezmapimod hydrochloride is an autophagy and mitophagy activator.

Specifications

Chemical Name or Material Adezmapimod hydrochloride
CAS 869185-85-3
Color Yellow
Purity Grade Notes Research
Molecular Formula C21H17ClFN3OS
Quantity 100 mg
Synonym SB 203580 hydrochlorideRWJ 64809 hydrochloride
Solubility Information DMSO : 100 mg/mL (241.60 mM; Need ultrasonic) ∣H2O : 8.43 mg/mL (20.37 mM; Need ultrasonic and warming)
SMILES O=S(C1=CC=C(C2=NC(C3=CC=C(F)C=C3)=C(C4=CC=NC=C4)N2)C=C1)C.[H]Cl
Molecular Weight (g/mol) 413.9
Formula Weight 413.9
Percent Purity 98.6%
Grade Research
Physical Form Powder
For Use With (Application) COVID-19-immunoregulation
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Research purposes only

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