Invitrogen™ ADORA2A/ADORA2B Monoclonal Antibody (599743)

Description

Reconstitute at 0.5 mg/mL in sterile PBS.

ADORA2A (Adenosine A2A Receptor) and ADORA2B (Adenosine A2B Receptor) are genes that encode G protein-coupled receptors (GPCRs) involved in the adenosine signaling pathway. These receptors play critical roles in various physiological processes by mediating the effects of adenosine, a nucleoside that functions as a signaling molecule. ADORA2A is predominantly expressed in the central nervous system, particularly in the brain, where it modulates neurotransmitter release, neuroprotection, and neuroinflammation. It has been implicated in neurological conditions such as Parkinson's disease, where its antagonists are being explored as potential therapeutic agents. ADORA2B, on the other hand, is more widely distributed in peripheral tissues, including the cardiovascular system, lungs, and immune cells. It is involved in regulating inflammatory responses, vascular tone, and tissue protection during hypoxic conditions. Dysregulation of ADORA2B signaling has been linked to various pathological conditions, including chronic inflammation, asthma, and ischemic injury. Understanding the distinct and overlapping roles of ADORA2A and ADORA2B is crucial for developing targeted therapies aimed at modulating adenosine signaling in diverse diseases. Research into these receptors provides valuable insights into their potential as therapeutic targets for treating neurological disorders, cardiovascular diseases, and inflammatory conditions.