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AIRE Rat anti-Mouse, Alexa Fluor® 488, Clone: 5H12, eBioscience™

Rat Monoclonal Antibody

Merk:  Affymetrix eBioscience 53-5934-80

Overige gegevens : Gewicht : 0.25000kg

 Bekijk meerdere types van dit product via de

Produktcode. 15332050

  • € 155.00 / 25 µg


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Beschrijving

Beschrijving

AIRE is a transcriptional regulator protein that binds to DNA as a dimer and tetramer, but not as a monomer, and may be involved in the regulation of gene expression. A nuclear protein, AIRE is a 545 amino acid protein with an HSR domain, two PHD type zinc fingers, and a SAND domain, and may be present in soluble high-molecular-weight complexes. It may form homodimer, homotetramer and also nuclear bodies and interacts with the transcriptional coactivator CBP and CREBBP. Three isoforms of AIRE are reported and one of them is predicted to be a candidate for nuclear-mediated decay (NMD). AIRE is involved in immune regulation and is known to mediate E3 ubiquitin ligase activity. Defects in AIRE are responsible for the rare autosomal-recessive systemic autoimmune disease termed autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED).
Specificatie

Specificatie

AIRE
Monoclonal
0.5 mg/mL
PBS with 0.1% gelatin and 0.09% sodium azide; pH 7.2
Q9Z0E3
AIRE; autoimmune regulator (automimmune polyendocrinopathy candidiasis ectodermal dystrophy); APS1; APSI; PGA1; APECED; AIRE protein; autoimmune regulator (APECED protein); autoimmune regulator (autoimmune polyendocrinopathy candidiasis ectodermal dystrophy); autoimmune regulator; AIRE1; OTTHUMP00000109529; autoimmune polyendocrinopathy candidiasis ectodermal dystrophy
Rat
Affinity chromatography
RUO
Antibody
Monoclonal
Mouse
Flow Cytometry, Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Frozen)
5H12
Alexa Fluor® 488
Aire
Liquid
Aire
IgG2c, kappa
25 μg
4° C, store in dark, DO NOT FREEZE!
Primary
11634
Video's

For Research Use Only.