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Invitrogen™ Akirin2 Polyclonal Antibody
Rabbit Polyclonal Antibody
Brand: Invitrogen™ PA534875
This item is not returnable.
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Description
Recommended positive controls: A549, HeLa, HCT116. Predicted reactivity: Mouse (95%), Rat (95%), Zebrafish (81%), Xenopus laevis (83%), Pig (98%), Chicken (94%), Sheep (97%), Chimpanzee (100%), Bovine (97%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
The highly conserved, nuclear-localized Akirin1 and Akirin2 proteins critically regulate the transcription of NF-kappa-B-dependent genes and are required for defense against Gram-negative bacteria in the immune deficiency and NF-kappa-B pathways. Akirin1 is dispensable in the mouse, and neither knockout mice nor cells derived from them have obvious distinctive phenotypes. In contrast, Akirin2 is required for development in the mouse and knockout of both Akirin homologs in mice show that Akirin2 is required downstream of toll-like receptor (TLR), TNF-a and IL-1-b signaling, and for the production of IL-6. Akirin2 is functionally closer to the single gene in Drosophila, as the homozygous null D. melanogaster Akirin mutants show a similar, mid-to-early embryonic death.
Specifications
| Akirin2 | |
| Polyclonal | |
| Unconjugated | |
| AKIRIN2 | |
| 14-3-3 beta; 2700059D21Rik; AA114675; AA522011; akirin 2; Akirin2; Akirin-2; akirin2 {ECO:0000250; AU019887; C6orf166; dJ486L4.2; EMBL:BAE81786.1}; FBI1; Fourteen-three-three beta interactant 1; fourteen-three-three beta interactant 1 {ECO:0000312; fourteen-three-three beta interacting-protein 1; RGD1307791; UniProtKB:Q53H80} | |
| Rabbit | |
| Antigen affinity chromatography | |
| RUO | |
| 55122 | |
| Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. | |
| Liquid |
| Western Blot | |
| 1 mg/mL | |
| 0.1M tris glycine with 20% glycerol and 0.01% thimerosal; pH 7 | |
| Q53H80 | |
| AKIRIN2 | |
| Recombinant protein encompassing a sequence within the center region of human Akirin 2. The exact sequence is proprietary. | |
| 100 μL | |
| Primary | |
| Human | |
| Antibody | |
| IgG |
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