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  5. Tocris Bioscience™ AKOS 022

Tocris Bioscience™ AKOS 022
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Product Code. 18797016
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Product Code. 18797016 Supplier Tocris Bioscience™ Supplier No. 7135/10

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Description

Voltage-dependent anion channel (VDAC) inhibitor

AKOS 022 is a voltage-dependent anion channel (VDAC; Kd = 154 μM) inhibitor, which reduces channel conductance. In HEK-293 cells, AKOS 022 inhibits selenium-induced VDAC oligomerization, cytochrome C release from mitochondria and apoptosis (IC50 values range from 3.3 to 3.6 μM). AKOS 022 also prevents glucotoxicity-mediated overexpression of VDAC1 in INS-1 cells.
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Specifications

Chemical Name or Material 1-(4-Chlorophenyl)-3-[4-[[4-(trifluoromethoxy)phenyl]amino]-1-piperidinyl]-2,5-pyrrolidinedione
CAS 878983-38-1
Quantity 10 mg
Target Ion Channel Modulators
Molecular Formula C22H21ClF3N3O3
Purity 0.98
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