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Invitrogen™ ALKBH5 Polyclonal Antibody

Product Code. 15760351 Shop All Thermo Scientific Products
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Quantity:
100 μL
Unit Size:
100µL
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15760351 100 μL 100µL
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Product Code. 15760351 Supplier Invitrogen™ Supplier No. PA552401

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Description

Rabbit Polyclonal Antibody

Immunogen sequence: EKLKSMTSRD NYKAGSREAA AAAAAAVAAA AAAAAAAEPY PVSGAKRKYQ EDSDPERSDY EEQQLQKEEE ARKVKSGIRQ MRLFSQDECA KIEARIDEVV SRAEKGLYNE HTVD Highest antigen sequence identity to the following orthologs: Mouse - 95%, Rat - 96%.

ALKBH5 (RNA demehtylase ALKBH5) is a dioxygenase that demethylates RNA by oxidative demethylation. Specifically, it demethylates N(6)-methyladenosine (m6A) RNA, the most prevalent internal modification of messenger RNA (mRNA) in higher eukaryotes. Demethylation of m6A mRNA affects mRNA processing and export. ALKBH5 can also demethylate N(6)-methyladenosine in single-stranded DNA (in vitro). It requires molecular oxygen, alpha-ketoglutarate and iron.
TRUSTED_SUSTAINABILITY

Specifications

Antigen ALKBH5
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 0.3 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene ALKBH5
Gene Accession No. Q6P6C2
Gene Alias ABH5; AlkB family member 5, RNA demethylase; alkB homolog 5, RNA demethylase; alkB, alkylation repair homolog 5; alkB, alkylation repair homolog 5 (E. coli); Alkbh5; Alkylated DNA repair protein alkB homolog 5; alpha-ketoglutarate-dependent dioxygenase alkB homolog 5; AW050020; AW215868; E130207K11; OFOXD; OFOXD1; oxoglutarate and iron-dependent oxygenase domain containing; probable alpha-ketoglutarate-dependent dioxygenase ABH5; RGD1309496; RNA demethylase ALKBH5
Gene Symbols ALKBH5
Host Species Rabbit
Immunogen Recombinant protein corresponding to Human ALKBH5. Recombinant protein control fragment (Product #RP-89694).
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 54890
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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