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Almorexant, MedChemExpress

Product Code. 16476877
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Product Code. 16476877 Supplier Medchem Express Supplier No. HY10805

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Description

MedChemExpress Almorexant (ACT 078573) is an orally active, potent and competitive dual orexin receptor antagonist, with Kd values of 1.3 nM (OX1) and 0.17 nM (OX2), respectively. Almorexant reversibly blocks signaling of orexin-A and orexin-B peptides. Almorexant totally blocked the intracellular Ca2+ signal pathway. Almorexant stimulates caspase-3 activity in AsPC-1 cells and induces apoptosis.

Almorexant (ACT 078573) is an orally active, potent and competitive dual orexin receptor antagonist, with Kd values of 1.3 nM (OX1) and 0.17 nM (OX2), respectively. Almorexant reversibly blocks signaling of orexin-A and orexin-B peptides. Almorexant totally blocked the intracellular Ca2+ signal pathway. Almorexant stimulates caspase-3 activity in AsPC-1 cells and induces apoptosis.

Specifications

Chemical Name or Material Almorexant
CAS 871224-64-5
Color White
Purity Grade Notes Research
Molecular Formula C29H31F3N2O3
Quantity 5 mg
Synonym ACT 078573
Solubility Information DMSO : ≥ 46 mg/mL (89.75 mM)
SMILES CNC([C@@H](C1=CC=CC=C1)N2CCC3=CC(OC)=C(OC)C=C3[C@@H]2CCC4=CC=C(C(F)(F)F)C=C4)=O
Molecular Weight (g/mol) 512.56
Formula Weight 512.56
Percent Purity 99.01%
Grade Research
Physical Form Solid
For Use With (Application) Neuroscience-Neuromodulation
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Research purposes only

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