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ALOX5 Monoclonal Antibody (OTI2D7), TrueMAB™, OriGene
Mouse Monoclonal Antibody
Brand: Origene Technologies TA807021
This item is not returnable.
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Description
The enzyme 5-lipoxygenase (5-LO) plays a key role in regulating the production of leukotrienes (LT ). Overproduction of LT contributes to several diseases, most notably chronic inflammatory diseases, including asthma, fibrosis and atherosclerosis. Recent work has demonstrated that the activity of 5-LO is regulated by PKA phosphorylation of serine-523 in 5-LO. Under normal conditions, this phosphorylation may be important in limiting inflammation. Abnormal signaling through cAMP and PKA, then, could contribute to a variety of diseases, including those characterized by chronic inflammation.Specifications
| ALOX5 | |
| Monoclonal | |
| 1 mg/mL | |
| PBS with 1% BSA, 50% glycerol and 0.02% sodium azide | |
| P09917 | |
| ALOX5 | |
| Human recombit protein fragment corresponding to amino acids 18-364 of human ALOX5 produced in E.coli. | |
| 100 μL | |
| Primary | |
| Human | |
| Antibody | |
| IgG1 |
| Western Blot | |
| OTI2D7 | |
| Unconjugated | |
| ALOX5 | |
| 5-LO, 5-LOX, 5LPG, LOG5 | |
| Mouse | |
| Affinity Chromatography | |
| RUO | |
| 240 | |
| -20° C, Avoid Freeze/Thaw Cycles | |
| Liquid |
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