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Invitrogen™ Amphiphysin Polyclonal Antibody
Goat Polyclonal Antibody
Brand: Invitrogen™ PA518513
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Description
This antibody is predicted to react with canine and rat based on sequence homology. This antibody is tested in Peptide ELISA: antibody detection limit dilution 16,000.
Amphiphysins, members of the BAR (Bin-Amphiphysin-Rvsp) protein super family, play a key role in clathrin-mediated endocytosis of synaptic vesicles (SVs). All members of the BAR family share a highly conserved N-terminal BAR domain and a C-terminal Src homology (SH3) domain. Two isoforms of amphiphysin have been identified and act in concert as a heterodimer. Amphiphysins interact via its carboxy-terminal SH3 domain with dynamin, synaptojanin and clathrin. These complexes are implicated in synaptic vesicle recycling at nerve terminal. Amphiphysins were also identified as the dominant autoantigen in paraneoplastic Stiff-Man Syndrome.
Specifications
| Amphiphysin | |
| Polyclonal | |
| Unconjugated | |
| Amph | |
| Amph; AMPH1; amphiphysin; amphiphysin (Stiff-Mann syndrome with breast cancer 128kD autoantigen); amphiphysin 1; amphiphysin I; HGNC:471 | |
| Goat | |
| Ammonium sulfate precipitation | |
| RUO | |
| 218038, 273 | |
| -20°C, Avoid Freeze/Thaw Cycles | |
| Liquid |
| Immunohistochemistry (Paraffin), Western Blot | |
| 0.5 mg/mL | |
| TBS with 0.5% BSA and 0.02% sodium azide; pH 7.3 | |
| P49418, Q7TQF7 | |
| Amph | |
| Synthetic peptide sequence (KRKDESRISKAE) corresponding to the internal amino acids of AMPH (aa 159-170). | |
| 100 μg | |
| Primary | |
| Human, Mouse | |
| Antibody | |
| IgG |
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