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Description
AMP-activated protein kinase (AMPK) is a heterotrimeric protein composed of a catalytic alpha subunit, a noncatalytic beta subunit, and a noncatalytic regulatory gamma subunit. Various forms of each of these subunits exist, encoded by different genes. AMPK is an important energy-sensing enzyme that monitors cellular energy status and functions by inactivating key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. This gene is a member of the AMPK gamma subunit family and encodes a protein with four cystathionine beta-synthase domains. Mutations in this gene have been associated with ventricular pre-excitation (Wolff-Parkinson-White syndrome), progressive conduction system disease and cardiac hypertrophy. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
Specifications
Specifications
| Antigen | AMPK gamma2 |
| Applications | Western Blot, Immunohistochemistry (Paraffin), Immunofluorescence, Immunocytochemistry |
| Classification | Polyclonal |
| Concentration | 0.17 mg/mL |
| Conjugate | Unconjugated |
| Formulation | PBS with 50% glycerol and 0.1% sodium azide; pH 7.3 |
| Gene | PRKAG2 |
| Gene Accession No. | Q91WG5, Q9UGJ0 |
| Gene Alias | AAKG, AAKG2, AMPK gamma2, AMPK subunit gamma 2, CMH6, H91620p, PRKAG2, WPWS |
| Gene Symbols | PRKAG2 |
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