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Invitrogen™ Angiopoietin 2 Polyclonal Antibody
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Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA523612

Product Code. 13218558

  • € 572.00 / 400µL

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Description

Description

Angiopoietin 2 Polyclonal Antibody for Western Blot, IHC (P), Flow

ANG-2 binds to the endothelial cell specific receptor Tie-2, but, in contrast to ANG-1, does not induce tyrosine phosphorylation. Consequently, ANG-2 modulates ANG-1 activation of Tie-2 and, depending on the physiological and biochemical environment, can act either as an agonist or antagonist of Tie-2 induced angiogenesis. The signaling interactions of ANG-1, ANG-2 and Tie-2, along with less characterized ANG-3 and ANG-4, are required for embryonic and adult angiogenesis. Physiologically, ANG-1 and ANG-2 are associated with sprouting, tube formation, and structural integrity of newly formed blood vessels. Mature human ANG-2 is a secreted protein containing 480 amino acid residues. ANG-2 is composed of an alpha-helix-rich coiled coil N-terminal domain and fibrinogen-like C-terminal domain. ANG-2 exists predominantly in the form of a disulfide-linked dimer.
TRUSTED_SUSTAINABILITY
Specifications

Specifications

Angiopoietin 2
Polyclonal
Unconjugated
ANGPT2
AGPT2; Ang2; Ang-2; angiopoietin 2; angiopoietin-2; angiopoietin-2a; angiopoietin-2B; ANGPT2; endothelial growth factor; Tie2-ligand
Rabbit
Antigen affinity chromatography, Protein A
RUO
11601, 285
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Liquid
Flow Cytometry, Immunohistochemistry (Paraffin), Western Blot
2.0 mg/mL
PBS with 0.09% sodium azide; pH 7.4
O15123, O35608
ANGPT2
KLH conjugated synthetic peptide between 404-432 amino acids from the C-terminal region of human ANGPT2.
400 μL
Primary
Human, Mouse
Antibody
IgG
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