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ACVR1, Mouse, Clone: 2D5, Abnova™

Mouse monoclonal antibody raised against a partial recombinant ACVR1.

Brand:  Abnova H00000090-M07.100ug

Product Code. 16174324

  • € 349.00 / 100µg

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Description

Description

Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I ( I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. This gene encodes activin A type I receptor which signals a particular transcriptional response in concert with activin type II receptors. Mutations in this gene are associated with fibrodysplasia ossificans progressive. [provided by RefSeq

Sequence: MEDEKPKVNPKLYMCVCEGLSCGNEDHCEGQQCFSSLSINDGFHVYQKGCFQVYEQGKMTCKTPPSPGQAVECCQGDWCNRNITAQLPTKGKSFPGTQNF
Specifications

Specifications

ACVR1
Monoclonal
Unconjugated
PBS with no preservative; pH 7.4
BC033867
ACVR1
ACVR1 (AAH33867, 21 a.a. ∼ 120 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
100 μg
Primary
Human
Antibody
IgG1 κ
ELISA, Western Blot
2D5
Mouse monoclonal antibody raised against a partial recombinant ACVR1.
ACVR1
ACTRI/ACVR1A/ACVRLK2/ALK2/FOP/SKR1/TSRI
Mouse
Affinity chromatography
RUO
90
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
Liquid
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