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at Anti-Blimp-1 Rat, Unlabeled, Clone: 6D3, BD
Rat Monoclonal Antibody
Brand: BD Biosciences 564703
This item is not returnable.
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Description
The 6D3 monoclonal antibody specifically binds to mouse B lymphocyte-induced maturation protein 1 (Blimp-1) and crossreacts with human BLIMP-1. Blimp-1 is a 98 kDa zinc finger-containing protein that is encoded by the Prdm1 gene. Blimp-1 was first discovered as a transcriptional repressor of the IFN- β promoter. Blimp-1 is critical for primordial germ cells specification in the early embryo and induction of terminal cell differentiation in multiple somatic cell types. It is largely known as a master regulator of antibody-secreting plasma cells due to its function in the repression of PAX5 , CIITA and cMYC genes. Blimp-1 also controls T cell homeostasis and effector differentiation through different mechanisms, including repression of IL-17 producing cells. Blimp-1 also plays roles in the maturation and activity of dendritic cells and natural killer cells.
Specifications
| at Anti-Blimp-1 | |
| Monoclonal | |
| 0.5mg/mL | |
| BLIMP-1; PRDM1; PR domain containing 1, with ZNF domain; PRDI-BF1 | |
| Rat | |
| Affinity Purified | |
| RUO | |
| Human, Mouse | |
| IgG2a κ |
| Flow Cytometry | |
| 6D3 | |
| Unconjugated | |
| Aqueous buffered solution containing ≤0.09% sodium azide. | |
| Mouse Blimp-1 Recombinant Protein | |
| 0.1 mg | |
| Primary | |
| Store undiluted at 4°C |
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