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c-Myc with control Mouse anti-Human, Unlabeled, Clone: 9E10., BD
Mouse Monoclonal Antibody
Brand: BD Biosciences 551101
This item is not returnable.
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Description
The myc gene family contains at least seven closely related genes, c-myc, N-myc, L-myc, P-myc, R-myc, S-myc, and B-myc. C-myc plays a role in proliferation, transformation, and differentiation. It is expressed during embryonic development, in a wide variety of adult tissues, and is amplified in many tumors, particularly lung, breast, cervical and colon carcinomas. Cellular localization has been described as nuclear and/or cytopasmic. C-myc has three sequence motifs in the carboxy terminus, a leucine zipper, a helix-loop-helix, and a basic region. It forms sequence-specific (CACGTG) DNA binding heterodimers with max, a helixloop-helix/leucine zipper protein. Both the leucine zipper domain and the helixloop-helix motif of c-myc contribute to heterodimer formation. DNA binding of myc-max dimers results in a conformational change of the DNA and transcriptional activation. C-myc migrates at 62 kDa in SDS-PAGE. Clone 9E10 recognizes human c-myc. A synthetic peptide corresponding to a C-terminal epitope of the human c-myc protein (AEEQKLISEEDL) was used as an immunogen.
Specifications
| c-Myc with control | |
| Monoclonal | |
| Unconjugated | |
| Affinity Purified | |
| RUO | |
| Purified Mouse Anti-Human c-Myc (50μg); Jurkat Cell Lysate (50μg) | |
| Store undiluted at -20°C. |
| Western Blot | |
| 9E10. | |
| Mouse | |
| 50 μg | |
| Primary | |
| Human | |
| IgG1 |
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