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Description
The purified I52-1486 antibody reacts with the mouse C5a protein. Anaphylatoxin C5a is a bioactive cleavage product released from plasma component C5 during complement activation and is involved in mediation of a variety of cellular immune responses, as well as being potent pro-inflammatory agents. The release of this cleavage product is a reliable indicator of in vivo or in vitro complement activation. Clone I52-1486 hybridoma was generated by the fusion of spleen cells from rats immunized with recombinant mouse C5a protein. The I52-1486 antibody is specific for a neoepitope exposed in mouse C5a/C5adesArg and does not cross-react with mouse C5. This capacity makes antibody I52-1486 a preferential capture antibody for direct detection of mouse C5a from plasma or serum samples.
This antibody is routinely tested by ELISA. Other applications were tested at BD Biosciences Pharmingen during antibody development only or reported in the literature.
Specifications
| C5a | |
| Monoclonal | |
| 0.5mg/mL | |
| Aqueous buffered solution containing ≤0.09% sodium azide. | |
| Recombinant mouse C5a | |
| 0.1 mg | |
| Immunology | |
| Mouse | |
| IgG1 κ |
| ELISA | |
| I52-1486 | |
| Unconjugated | |
| Rat | |
| Affinity Purified | |
| RUO | |
| Primary | |
| Store undiluted at 4°C |
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