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CD106 Rat anti-Mouse, Biotin, Clone: 429 (MVCAM.A), BD

Product Code. 15807158
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Product Code. 15807158 Supplier BD Biosciences Supplier No. 553331

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Description

Rat Monoclonal Antibody

The 429 monoclonal antibody specifically binds to both the long (∽110 kDa) transmembrane-spanning form and the truncated (∽47 kDa) GPI-linked form of vascular cell adhesion molecule-1 (VCAM-1, CD106). CD106 is constitutively expressed on bone marrow stromal cells, myeloid cells, and splenic dendritic cells. Its expression on endothelial cells is upregulated by inflammatory cytokines and in certain pathologic conditions. CD106 expression has also been detected on apoptotic thymocytes, splenocytes, and lymphoid cell lines. VCAM-1 is a counter-receptor for VLA-4 (α4β1 integrin) and LPAM-1 (α4β7 integrin), and the 429 antibody partially blocks VCAM-1-mediated binding functions. Source of the immunogen was the mouse preadipose cell line PA6.

TRUSTED_SUSTAINABILITY

Specifications

Antigen CD106
Applications Flow Cytometry
Classification Monoclonal
Clone 429 (MVCAM.A)
Concentration 0.5mg/mL
Conjugate Biotin
Description Vcam-1; Vascular cell adhesion molecule 1; Vascular cell adhesion protein 1
Formulation Aqueous buffered solution containing ≤0.09% sodium azide.
Host Species Rat
Immunogen Mouse preadipose cell line PA6
Purification Method Affinity Purified
Quantity 0.5 mg
Regulatory Status RUO
Research Discipline Immunology
Primary or Secondary Primary
Target Species Mouse
Content And Storage Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Isotype IgG2a κ
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For Research Use Only.

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