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CD123 Mouse anti-Human, PerCP-Cy5.5, Clone: 7G3, BD
Mouse Monoclonal Antibody
Brand: BD Biosciences 558714
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Description
Reacts with human CD123, the 70 kD IL-3 receptor α chain (IL-3Rα), which associates with the 120-140kDa β subunit. The β chain is shared with the receptors for interleukins IL-5 and GM-CSF. IL-3Rα is expressed on hematopoietic progenitors. This antibody has been reported to block the binding of 125I-IL-3 to high and low affinity IL-3 receptors. In functional experiments, this antibody was found to inhibit acute myeloid leukemia cell proliferation, basophil histamine release, endothelial cell-mediated IL-8 secretion, and neutrophil transmigration. This antibody has been reported to be useful for immunoprecipitation, western blot and immunofluorescent staining for flow cytometry. IL-3Rα plays an important role in hematopoietic progenitor cell growth and differentiation. At the Fifth HLDA Workshop, the human IL-3 receptor was designated CD123.
Flow Cytometry
Specifications
| CD123 | |
| Monoclonal | |
| PerCP-Cyanine5.5 | |
| Aqueous buffered solution containing BSA and ≤0.09% sodium azide. | |
| Human IL-3Ra-transfected cells | |
| RUO | |
| Primary | |
| Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze. |
| Flow Cytometry | |
| 7G3 | |
| IL3RA; IL-3RA; IL-3Rα; IL-3R-alpha; Interleukin-3 receptor subunit alpha | |
| Mouse | |
| 100 Tests | |
| Immunology | |
| Human | |
| IgG2a κ |
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