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CD134 Mouse anti-Human, PerCP-Cy5.5, Clone: ACT35 (also known as Ber-ACT35), BD

Product Code. 15822979
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Product Code. 15822979 Supplier BD Biosciences Supplier No. 563659

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Description

Mouse Monoclonal Antibody

The ACT35 monoclonal antibody specifically binds to CD134 which is also known as OX40. The 35 kDa CD134 polypeptide is encoded by the TNFRSF4 gene. CD134 is a type I integral membrane glycoprotein and member of the tumor necrosis factor/nerve growth factor receptor (TNFR/NGFR) family. CD134 is expressed on activated T lymphocytes, hematopoietic precursor cells and fibroblasts. CD134 functions as a T cell costimulatory receptor when bound by OX40 Ligand/TNFSF4 that is expressed by antigen presenting cells. CD134 thereby plays roles in T-cell activation as well as the regulation of differentiation, proliferation or apoptosis of normal and malignant lymphoid cells. Analysis of the nucleotide sequence of the human TNFRSF4 cDNA reveals strong homology with the rat Tnfrsf4 cDNA sequence. OX40 was clustered as CD134 in the Sixth International Workshop on Human Leukocyte Differentiation Antigens.

TRUSTED_SUSTAINABILITY

Specifications

Antigen CD134
Applications Flow Cytometry
Classification Monoclonal
Clone ACT35 (also known as Ber-ACT35)
Conjugate PerCP-Cyanine5.5
Description OX40; TNFRSF4; TXGP1L; OX40L Receptor
Host Species Mouse
Immunogen Human HUT 102
Purification Method Affinity Purified
Quantity 50 Tests
Regulatory Status RUO
Primary or Secondary Primary
Target Species Human
Content And Storage Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Isotype IgG1 κ
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