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CD138 Rat anti-Mouse, APC, Clone: 281-2, BD
Rat Monoclonal Antibody
Brand: BD Biosciences 561705
This item is not returnable.
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Description
The 281-2 antibody reacts with the core protein of CD138 (Syndecan-1), a cell-surface, integral membrane heparan sulfate- and chondroitin sulfate-containing proteoglycan that binds to interstitial extracellular matrix molecules. Syndecan-1 is predominantly expressed on epithelial cells, where its expression correlates with normal epithelial organization. It is also expressed on B lymphocytes at specific stages during their differentiation: precursor B cells in the bone marrow and antibody-secreting cells, including plasma cells, but not mature peripheral B cells. It is thus implicated in mediating B cell-matrix interactions. CD138 expression is also regulated during embryonic development, and the molecule shows a tissue- specific structural polymorphism resulting from different post-translational modifications. The 281-2 antibody may be used to detect the differently glycosylated forms, because it reacts with the core protein. Furthermore, the mAb detects the Syndecan-1 ectodomain which is cleaved from cell surfaces by a metalloproteinase.
Flow Cytometry
Specifications
| CD138 | |
| Monoclonal | |
| 0.2mg/mL | |
| SYND1; Syndecan-1; syn-1; Sdc1; Sstn; synstatin | |
| Rat | |
| Affinity Purified | |
| RUO | |
| Mouse | |
| IgG2a κ |
| Flow Cytometry | |
| 281-2 | |
| APC | |
| Aqueous buffered solution containing ≤0.09% sodium azide. | |
| NAMRU mouse mammary gland epithelial cell line NMuMG | |
| 25 μg | |
| Primary | |
| Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze. |
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