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  6. CD152 Mouse anti-Human, APC, Clone: BNI3, BD

CD152 Mouse anti-Human, APC, Clone: BNI3, BD

Product Code. 15888488
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15888488 100 Tests Each
15820619 25 Tests Each
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Product Code. 15888488 Supplier BD Biosciences Supplier No. 555855

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Description

Mouse Monoclonal Antibody

Reacts with the “cytolytic T lymphocyte-associated antigen”, CTLA-4. CTLA-4 is transiently expressed on activated CD28+ T cells and binds to CD80 and CD86 present on antigen presenting cells (APC) with high avidity. This interaction appears to deliver a negative regulatory signal to the T cell. There are recent reports that indicate that CTLA-4 is also expressed on B cells when cultured with activated T cells, suggesting a possible role of CTLA-4 in the regulation of B-cell response. Immobilized BNI3.1 enhances T-cell proliferation induced by CD3 and CD28. Recent studies have showed that CD152 can be expressed by regulatory T (Treg) cells. It has been found this antibody can stain the
intracellular CD152 on the Treg cells after fixation and permeabilization of cells.

Host Species: Mouse
Clone: BNI3
Isotype: IgG2a κ
Species Reactivity: Human

Flow Cytometry, Intracellular Staining

TRUSTED_SUSTAINABILITY

Specifications

Antigen CD152
Applications Flow Cytometry
Classification Monoclonal
Clone BNI3
Conjugate APC
Description CTLA-4; AILIM; Cytotoxic T-lymphocyte protein 4
Formulation Aqueous buffered solution containing BSA and ≤0.09% sodium azide.
Host Species Mouse
Immunogen Human CTLA4 Recombinant Protein
Purification Method Affinity Purified
Quantity 100 Tests
Regulatory Status RUO
Research Discipline Immunology
Primary or Secondary Primary
Target Species Human
Content And Storage Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Isotype IgG2a κ
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For Research Use Only.

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