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CD18 Rat anti-Mouse, NA/LE, Unlabeled, Clone: GAME-46, BD

Product Code. 15858038
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Product Code. 15858038 Supplier BD Biosciences Supplier No. 555280

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Description

Rat Monoclonal Antibody

The GAME-46 antibody reacts with the common β2 chain of LFA-1 (CD11a/CD18, αLβ2 integrin), Mac-1 (CD11b/CD18, αMβ2 integrin), and gp150, 95 (CD11c/CD18, αXβ2 integrin). Expression of CD18 is limited to leukocytes, where it is widely distributed in consort with each of the three integrin α chains (CD11a, CD11b, and CD11c). Among splenocytes, NK cells have the highest density of CD18, and T lymphocytes express a higher density than the remaining cells. The β2 integrins are important mediators of leukocyte-endothelium interactions. It has been reported that GAME-46 antibody blocks in vitro adhesion of LFA-1-expressing cells to the ligands ICAM-1, ICAM-2 and ICAM-3 and of Mac-1-expressing cells to ICAM-1, C3bi, and fibrinogen.

TRUSTED_SUSTAINABILITY

Specifications

Antigen CD18
Applications Flow Cytometry
Classification Monoclonal
Clone GAME-46
Concentration 1.0mg/mL
Conjugate Unconjugated
Description Integrin β2 chain
Formulation No azide/low endotoxin: Aqueous buffered solution containing no preservative, 0.2μm sterile filtered. Endotoxin level is ≤0.01 EU/μg (≤0.001 ng/μg) of protein as determined by the LAL assay.
Host Species Rat
Immunogen LFA-1 (CD11a/CD18) from mouse T-cell hybridoma TAM8C41
Purification Method Affinity Purified
Quantity 0.5 mg
Regulatory Status RUO
Research Discipline Immunology
Primary or Secondary Primary
Target Species Mouse
Content And Storage Store undiluted at 4°C
Isotype IgG1 κ
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For Research Use Only.

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