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CD195 Mouse anti-Human, PE, Clone: 3A9, BD
Mouse Monoclonal Antibody
Brand: BD Biosciences 550632
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Description
Reacts with the chemokine receptor, CCR5, a seven transmembrane-spanning G protein-associated molecule. 3A9 antibody has also been reported to cross-react with human CCR8. Results of epitope mapping and sequence comparison between CCR5 and CCR8 reveals that the first three amino acid residues for these two receptors are identical: MDY (Met-Asp-Tyr). CCR5 belongs to the β-chemokine receptor family. It is expressed on a subset of T lymphocytes (CD3+, CD45RO+, CD95+). CCR5 regulates lymphocyte chemotaxis activation and transendothelial migration during inflammation. It signals a response to at least three chemokines: RANTES and macrophage inflammatory protein-1 (MIP-1) α and β. Additionally, CCR5 has been found to be a co-receptor for macrophage-tropic HIV-1 on CD4+ cells, a characteristic that is important in viral transmission. Reports indicate that individuals who have partial (heterozygous) or complete (homozygous) deletion of the CCR5 allele, demonstrate resistance to HIV infection. CCR5 has been clustered as CD195 in the VIIth HLDA workshop. This antibody is routinely tested by flow cytometric analysis. Other applications were tested at BD Biosciences Pharmingen during antibody development only or reported in the literature.
Specifications
| CD195 | |
| Monoclonal | |
| PE | |
| Aqueous buffered solution containing BSA and ≤0.09% sodium azide. | |
| Human CCR5 Transfected Cell Line | |
| 50 Tests | |
| Immunology | |
| Cynomolgus, Rhesus Monkey | |
| IgG2a κ |
| Flow Cytometry | |
| 3A9 | |
| CCR5 | |
| Mouse | |
| Affinity Purified | |
| RUO | |
| Primary | |
| Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze. |
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