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  6. CD27 Mouse anti-Human, BUV395, Clone: L128, BD

CD27 Mouse anti-Human, BUV395, Clone: L128, BD

Product Code. 15873119
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100 Tests
25 Tests
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15873119 25 Tests Each
15863119 100 Tests Each
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Product Code. 15873119 Supplier BD Biosciences Supplier No. 563816

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Description

Mouse Monoclonal Antibody

The L128 monoclonal antibody specifically binds to human CD27. CD27 is a 55-kDa disulfide-linked dimer that is a member of the nerve growth factor (NGF) super family. This family also includes CD40, rat OX40, tumor necrosis factor (TNF) receptors and CD95 (Fas). With its ligand CD70, CD27 acts in a co-stimulatory fashion on T lymphocytes. Present on most peripheral blood T lymphocytes and medullary thymocytes, the CD27 antigen is upregulated upon activation with the release of a soluble form, 28 to 32 kDa. It is also detected on a subpopulation of approximately 33% of circulating B lymphocytes. Following exposure to antigens, CD45RA+ T lymphocytes respond by upregulating the CD27 antigen. After maximal stimulation, the CD27 antigen cannot be re-expressed on long-term cultures or on CD45RA-CD27+ T lymphocytes. The CD4+CD27- population is contained within the memory CD45RO+ subset that proliferates after exposure to allergens. Two subpopulations of B lymphocytes bearing the CD27 antigen secrete IgM ( δ +) and IgG ( δ -).

TRUSTED_SUSTAINABILITY

Specifications

Antigen CD27
Applications Flow Cytometry
Classification Monoclonal
Clone L128
Conjugate Brilliant Ultraviolet 395
Description TNFRSF7; Tumor necrosis factor receptor superfamily, member 7; Tp55; S152
Formulation Aqueous buffered solution containing BSA and ≤0.09% sodium azide.
Host Species Mouse
Immunogen Human Activated Peripheral Blood Cells
Purification Method Affinity Purified
Quantity 25 Tests
Regulatory Status RUO
Primary or Secondary Primary
Target Species Human
Content And Storage Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Isotype IgG1
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