missing translation for 'onlineSavingsMsg'
Learn More
Learn More
This item is not returnable.
View return policy
Description
The OX-79 antibody reacts with CD53, a 35-45-kDa member of the Transmembrane 4-pass protein superfamily (TM4SF). As in the human, mouse peripheral leukocytes express CD53 mRNA and protein, and erythrocytes and nonhematopoietic cells do not. However, the distribution of CD53 in the mouse and rat thymus differs from that in the human. In the mouse, most CD4+8- and major subsets of CD4- CD8- (double-negative) and CD4- CD8+ thymocytes express CD53, while most cortical CD4+ CD8+ (double-positive) thymocytes are CD53-low or CD53-negative. CD53 expression can be induced in double-positive thymocytes by cross-linking of their T-cell receptors with anti-TCR mAb or peptide-pulsed antigen-presenting cells. There is a strong correlation between positive selection of thymocytes and CD53 expression. Its association with CD2 and a tyrosine phosphatase in rat T lymphocytes and with CD19, CD21, HLA-DR, and other TM4SF proteins in human B lymphocytes suggests that CD53 is involved in leukocyte signal transduction.
Specifications
| CD53 | |
| Monoclonal | |
| 0.2mg/mL | |
| Cd53: Ox-44; Tspan25; Tetraspanin-25 | |
| Rat | |
| Affinity Purified | |
| RUO | |
| Mouse | |
| IgM κ |
| Flow Cytometry | |
| OX-79 | |
| Alexa Fluor 647 | |
| Aqueous buffered solution containing protein stabilizer and ≤0.09% sodium azide | |
| BAB/14 mouse macrophage cell line RAW 264 | |
| 50 μg | |
| Primary | |
| Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze. |
Product Content Correction
Your input is important to us. Please complete this form to provide feedback related to the content on this product.
Product Title
Spot an opportunity for improvement?Share a Content Correction