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  6. Cyclin D1 Mouse anti-Human, Unlabeled, Clone: G124-326, BD

Cyclin D1 Mouse anti-Human, Unlabeled, Clone: G124-326, BD

Product Code. 15837608
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Product Code. 15837608 Supplier BD Biosciences Supplier No. 554181

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Description

Mouse Monoclonal Antibody

Cyclins and cyclin-dependent kinases (cdks) are evolutionarily conserved proteins that are essential for cell-cycle control in eukaryotes. Cyclins contain a conserved amino acid sequence motif, the cyclin box, which allows their binding to cdks to form active complexes that regulate the progression of the cell cycle. The synthesis and degradation of cyclins is tightly controlled in a cell cycle specific manner. Several classes of cyclins (A-E) have been described. Cyclins have been placed into functional groups as follows: Group 1 (cyclins A, B, D1, D2, D3, E and F) functions primarily in cell cycle reguation; Group 2 (cyclins C and H) also plays a role in transcriptional regulation; Group 3 (cyclins G1, G2 and I) may play a role distinct from other cyclins. Specific substrates for cyclin-cdk complexes include nuclear lamins, histones, oncogenes (c-src, c-abl, SV40 large-T Ag), tumor suppressor genes (Rb and p53), and others. The D-type cyclins are involved in regulating the passage of mammalian cells through G1. The reduced molecular weights of cyclin D1 is ∽36kda. G124-326 recognizes human cyclin D1 and cross-reacts with the mouse homolog (Cyl1) of human cyclin D1. It does not cross-react with human cyclins D2 and D3. Recombinant full-length human cyclin D1 was used as immunogen.

Host Species: Mouse
Clone: G124-326
Isotype: IgG1
Species Reactivity: Human
Immunogen: Recombinant full-length human cyclin D1
Formula Weight [Chemical]: 36kDa

Flow Cytometry, Immunoprecipitation, Western Blotting

TRUSTED_SUSTAINABILITY

Specifications

Antigen Cyclin D1
Applications Western Blot
Classification Monoclonal
Clone G124-326
Concentration 0.5mg/mL
Conjugate Unconjugated
Formulation Aqueous buffered solution containing ≤0.09% sodium azide.
Host Species Mouse
Immunogen Recombinant full-length human cyclin D1
Purification Method Affinity Purified
Quantity 0.25 mg
Regulatory Status RUO
Research Discipline Cell Biology
Primary or Secondary Primary
Target Species Human, Mouse
Content And Storage Store undiluted at 4°C
Isotype IgG1
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For Research Use Only.

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