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  6. 16197414

E2F4, Mouse, Clone: 5B7, Abnova™

Mouse monoclonal antibody raised against a partial recombinant E2F4.

Brand:  Abnova H00001874-M01.100ug

Product Code. 16197414

  • € 349.00 / 100µg

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Description

Description

The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein binds to all three of the tumor suppressor proteins pRB, p107 and p130, but with higher affinity to the last two. It plays an important role in the suppression of proliferation-associated genes, and its gene mutation and increased expression may be associated with human cancer. [provided by RefSeq

Sequence: PPEDLLQSPSAVSTPPPLPKPALAQSQEASRPNSPQLTPTAVPGSAEVQGMAGPAAEITVSGGPGTDSKDSGELSSLPLGPTTLDTRPLQ*
Specifications

Specifications

E2F4
Monoclonal
Unconjugated
PBS with no preservative; pH 7.4
NM_001950
E2F4
E2F4 (NP_001941, 211 a.a. ∼ 300 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
100 μg
Primary
Human
Antibody
IgG1 κ
ELISA, Western Blot
5B7
Mouse monoclonal antibody raised against a partial recombinant E2F4.
E2F4
E2F-4
Mouse
Affinity chromatography
RUO
1874
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
Liquid
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