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F8, Rabbit, MaxPab™ Polyclonal Antibody, Abnova™

Rabbit polyclonal antibody raised against a full-length human F8 protein.

Brand:  Abnova H00002157-D01.100uL

Product Code. 16107894

  • € 365.00 / 100µL

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Description

Description

This gene encodes coagulation factor VIII, which participates in the intrinsic pathway of blood coagulation; factor VIII is a cofactor for factor IXa which, in the presence of Ca+2 and phospholipids, converts factor X to the activated form Xa. This gene produces two alternatively spliced transcripts. Transcript variant 1 encodes a large glycoprotein, isoform a, which circulates in plasma and associates with von Willebrand factor in a noncovalent complex. This protein undergoes multiple cleavage events. Transcript variant 2 encodes a putative small protein, isoform b, which consists primarily of the phospholipid binding domain of factor VIIIc. This binding domain is essential for coagulant activity. Defects in this gene results in hemophilia A, a common recessive X-linked coagulation disorder. [provided by RefSeq]

Sequence: MRIQDPGKVFFGNVDSSGIKHNIFNPPIIARYIRLHPTHYSIRSTLRMELMGCDLNSCSMPLGMESKAISDAQITASSYFTNMFATWSPSKARLHLQGRSNAWRPQVNNPKEWLQVDFQKTMKVTGVTTQGVKSLLTSMYVKEFLISSSQDGHQWTLFFQNGKVKVFQGNQDSFTPVVNSLDPPLLTRYLRIHPQSWVHQIALRMEVLGCEAQDLY
Specifications

Specifications

F8
Polyclonal
Rabbit polyclonal antibody raised against a full-length human F8 protein.
F8
AHF/DXS1253E/F8B/F8C/FVIII/HEMA
Rabbit
100 μL
Primary
Human
Liquid
Immunoprecipitation, Western Blot
Unconjugated
No additive
NM_019863.2
F8
F8 (NP_063916.1, 1 a.a. ∼ 216 a.a) full-length human protein.
RUO
2157
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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