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flap structure-specific endonuclease 1, Mouse, Clone: 1E2, Abnova™

Mouse monoclonal antibody raised against a partial recombinant FEN1.

Brand:  Abnova H00002237-M01A.200uL

Product Code. 16128064

  • € 349.00 / 200µL

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Description

Description

The protein encoded by this gene removes 5' overhanging flaps in DNA repair and processes the 5' ends of Okazaki fragments in lagging strand DNA synthesis. Direct physical interaction between this protein and AP endonuclease 1 during long-patch base excision repair provides coordinated loading of the proteins onto the substrate, thus passing the substrate from one enzyme to another. The protein is a member of the XPG/RAD2 endonuclease family and is one of ten proteins essential for cell-free DNA replication. DNA secondary structure can inhibit flap processing at certain trinucleotide repeats in a length-dependent manner by concealing the 5' end of the flap that is necessary for both binding and cleavage by the protein encoded by this gene. Therefore, secondary structure can deter the protective function of this protein, leading to site-specific trinucleotide expansions. [provided by RefSeq]

Sequence: MGIQGLAKLIADVAPSAIRENDIKSYFGRKVAIDASMSIYQFLIAVRQGGDVLQNEEGETTSHLMGMFYRTIRMMENGIKPVYVFDGKPPQLKSGELAKRSERRAEAEKQ
Specifications

Specifications

flap structure-specific endonuclease 1
Monoclonal
Unconjugated
ascites with no preservative
NM_004111
FEN1
FEN1 (NP_004102, 1 a.a. ∼ 110 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
RUO
Primary
Human
Antibody
IgM κ
ELISA, Western Blot
1E2
Mouse monoclonal antibody raised against a partial recombinant FEN1.
FEN1
FEN-1/MF1/RAD2
Mouse
200 μL
Yes
2237
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
Ascites
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