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homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1, Mouse, Clone: 3E10, Abnova™
Mouse monoclonal antibody raised against a full-length recombinant HERPUD1.
Brand: Abnova H00009709-M01.100ug
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Description
The accumulation of unfolded proteins in the endoplasmic reticulum (ER) triggers the ER stress response. This response includes the inhibition of translation to prevent further accumulation of unfolded proteins, the increased expression of proteins involved in polypeptide folding, known as the unfolded protein response (UPR), and the destruction of misfolded proteins by the ER-associated protein degradation (ERAD) system. This gene may play a role in both UPR and ERAD. Its expression is induced by UPR and it has an ER stress response element in its promoter region while the encoded protein has an N-terminal ubiquitin-like domain which may interact with the ERAD system. This protein has been shown to interact with presenilin proteins and to increase the level of amyloid-beta protein following its overexpression. Alternative splicing of this gene produces multiple transcript variants, some encoding different isoforms. The full-length nature of all transcript variants has not been determined. [provided by RefSeq
Sequence: MESETEPEPVTLLVKSPNQRHRDLELSGDRGWSVGHLKAHLSRVYPERPRPEDQRLIYSGKLLLDHQCLRDLLPKQEKRHVLHLVCNVKSPSKMPEINAKVAESTEEPAGSNRGQYPEDSSSDGLRQREVLRNLSSPGWENISRPEAAQQAFQGLGPGFSGYTPYGWLQLSWFQQIYARQYYMQYLAATAASGAFVPPPSAQEIPVVSAPAPAPIHNQFPAENQPANQNAAPQVVVNPGANQNLRMNAQGGPIVEEDDEINRDWLDWTYSAATFSVFLSILYFYSSLSRFLMVMGATVVMYLHHVGWFPFRPRPVQNFPNDGPPPDVVNQDPNNNLQEGTDPETEDPNHLPPDRDVLDGEQTSPSFMSTAWLVFKTFFASLLPEGPPAIANSpecifications
| homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 | |
| Monoclonal | |
| Unconjugated | |
| PBS with no preservative; pH 7.4 | |
| BC000086 | |
| HERPUD1 | |
| HERPUD1 (AAH00086, 1 a.a. ∼ 391 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. | |
| 100 μg | |
| Yes | |
| 9709 | |
| Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. | |
| IgG1 κ |
| ELISA, Western Blot | |
| 3E10 | |
| Mouse monoclonal antibody raised against a full length recombinant HERPUD1. | |
| HERPUD1 | |
| HERP/KIAA0025/Mif1/SUP | |
| Mouse | |
| Affinity Purified | |
| RUO | |
| Primary | |
| Human | |
| Antibody |
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