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Description
The C8.6 antibody reacts with human IL-12 p40 monomers, homodimers, and p70 heterodimers, but not p35 subunits. The immunogen used to generate the C8.6 hybridoma was the purified p40 subunit of human IL-12. The C8.6 antibody is a neutralizing antibody and has been reported to strongly inhibit three different biological activities of IL-12 (i.e., IFN-γ induction), mitogenic effects on PHA blasts, and enhancement of NK cell-mediated cytotoxicity. C8.6 has been shown to immunoprecipitate IL-23. This antibody is routinely tested by ELISA as a detection antibody. Other applications were tested at BD Biosciences Pharmingen during antibody development only or reported in the literature.
Host Species: Mouse
Clone: C8.6
Isotype: IgG1
Species Reactivity: Human
Immunogen: Purified p40 Subunit of Human IL-12
ELISA
Specifications
| IL-12 (p40/p70) | |
| Monoclonal | |
| 0.5mg/mL | |
| Aqueous buffered solution containing ≤0.09% sodium azide. | |
| Purified p40 Subunit of Human IL-12 | |
| 0.5 mg | |
| Immunology | |
| Human | |
| IgG1 κ |
| ELISA | |
| C8.6 | |
| Biotin | |
| Mouse | |
| Affinity Purified | |
| RUO | |
| Primary | |
| Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze. |
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