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IL-17F Mouse anti-Mouse, Alexa Fluor 647, Clone: O79-289, BD
Mouse Monoclonal Antibody
Brand: BD Biosciences 561630
This item is not returnable.
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Description
The O79-289 monoclonal antibody specifically binds to the inflammatory cytokine protein, Interleukin-17 (IL-17F). IL-17F is a member of the IL-17 family of cytokines. Among IL-17 family members, IL-17F has the highest amino acid sequence homology to IL-17A. IL-17F is produced by activated CD4+ T helper (Th17) cells, CD8+ T (Tc17) cells and γδ T cells. IL-17F can be secreted as homodimers or as heterodimers with IL-17A. IL-17F and IL-17A have overlapping functions such as inducing epithelial cells and fibroblasts to produce proinflammatory cytokines and chemokines including IL-6, GM-CSF, CXCL1, CCL2, and CCL7. These factors attract and activate neutrophils and other cell types that mediate protective responses against pathogenic microbes or pathologic allergic or autoimmune diseases. IL-17 gene knockout studies have shown that IL-17F and IL-17A have independent functions as well. IL-17F and IL-17A exert their biological function by binding to and signaling through IL-17 receptors comprised of the transmembrane receptor subunits, IL-17RA (CD217) and IL-17RC.
Specifications
| IL-17F | |
| Monoclonal | |
| 0.2mg/mL | |
| Il17f; interleukin 17F; Interleukin-17F | |
| Mouse | |
| Affinity Purified | |
| RUO | |
| Mouse | |
| IgG1 κ |
| Flow Cytometry | |
| O79-289 | |
| Alexa Fluor 647 | |
| Aqueous buffered solution containing ≤0.09% sodium azide. | |
| Mouse IL-17F Recombinant Protein | |
| 0.1 mg | |
| Primary | |
| Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze. |
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