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mitogen-activated protein kinase 10, Mouse, Clone: 3A3-1A8, Abnova™

Product Code. 16159631
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Quantity:
100 μg
Unit Size:
100µg
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16159631 100 μg 100µg
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Product Code. 16159631 Supplier Abnova Supplier No. H00005602M03.100ug

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Description

Mouse monoclonal antibody raised against a full-length recombinant MAPK10.

The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This protein is a neuronal-specific form of c-Jun N-terminal kinases (JNKs). Through its phosphorylation and nuclear localization, this kinase plays regulatory roles in the signaling pathways during neuronal apoptosis. Beta-arrestin 2, a receptor-regulated MAP kinase scaffold protein, is found to interact with, and stimulate the phosphorylation of this kinase by MAP kinase kinase 4 (MKK4). Cyclin-dependent kianse 5 can phosphorylate, and inhibit the activity of this kinase, which may be important in preventing neuronal apoptosis. Four alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq

Sequence: MELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR

Specifications

Antigen mitogen-activated protein kinase 10
Applications ELISA, Western Blot
Classification Monoclonal
Clone 3A3-1A8
Conjugate Unconjugated
Description Mouse monoclonal antibody raised against a full length recombinant MAPK10.
Formulation PBS with no preservative; pH 7.4
Gene MAPK10
Gene Accession No. BC065516
Gene Alias FLJ12099/FLJ33785/JNK3/JNK3A/MGC50974/PRKM10/p493F12/p54bSAPK
Gene Symbols MAPK10
Host Species Mouse
Immunogen MAPK10 (AAH65516.1, 1 a.a. ∼ 319 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification Method Affinity Purified
Quantity 100 μg
Regulatory Status RUO
Research Discipline Kinases
Whole Molecule Yes
Primary or Secondary Primary
Gene ID (Entrez) 5602
Target Species Human
Content And Storage Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
Product Type Antibody
Isotype IgG1 κ
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