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  6. Nedd4 Mouse anti-Mouse, Unlabeled, Clone: 15, BD
  7. 15845949

Nedd4 Mouse anti-Mouse, Unlabeled, Clone: 15, BD

Mouse Monoclonal Antibody

Brand:  BD Biosciences 611480

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Product Code. 15845949

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    € 251.00
    € 249.85 / 1 set
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Description

Description

Regulated protein degradation involves conjugation of ubiquitin to proteins for degradation by the 26S proteasome. Protein ubiquitination is the end product of a multienzyme cascade that involves sequential thiol-ester bond interactions between ubiquitin and enzymes termed E1-E3. Neuronal precursor cell-expressed developmentally down-regulated 4 (Nedd4) is a multimodular ubiquitin protein ligase E3 that contains a Ca2+;-lipid binding domain (CaLB), 3 WW domains, and a C-terminal ubiquitin protein ligase hect domain. The CaLB is characteristic of C2 domain-containing proteins, such as PKC, phospholipase C, phospholipase A2, and synaptogamin. Nedd4 is expressed differentially in the fetal and adult brain and its highest expression is in lung and kidney. Although it localizes in the cytoplasm, increased intracellular Ca 2+ induces plasma membrane association of Nedd4. In addition, increases in intracellular Na+ leads to Nedd4 binding to epithelial Na+ channels via its WW domains, which results in targeting of Na+ channels for degradation. Thus, the subcellular localization and protein interactions of Nedd4 are regulated in a Ca2+;- and Na+-dependent manner.

Host Species: Mouse
Clone: 15
Isotype: IgG1
Species Reactivity: Mouse
Immunogen: Mouse Nedd4 aa. 173-262
Formula Weight [Chemical]: 110kDa

Immunofluorescence, Western Blotting

TRUSTED_SUSTAINABILITY
Specifications

Specifications

Nedd4
Monoclonal
250μg/mL
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Mouse Nedd4 aa. 173-262
50 μg
Cell Biology
Mouse
IgG1
Western Blot
15
Unconjugated
Mouse
Affinity Purified
RUO
Primary
Store undiluted at -20°C.
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