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presenilin 1, Mouse, Polyclonal Antibody, Abnova™
Mouse polyclonal antibody raised against a partial recombinant PSEN1.
Brand: Abnova H00005663-A01.50uL
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Description
Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1; PSEN2) or in the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor, such that they either directly regulate gamma-secretase activity or themselves are protease enzymes. Several alternatively spliced transcript variants encoding different isoforms have been identified for this gene, the full-length nature of only some have been determined. [provided by RefSeq]
Sequence: PALIYSSTMVWLVNMAEGDPEAQRRVSKNSKYNAESTERESQDTVAENDDGGFSEEWEAQRDSHLGPHRSTPESRAAVQELSSSILAGEDPEERGVKLGLSpecifications
| presenilin 1 | |
| Polyclonal | |
| Mouse polyclonal antibody raised against a partial recombinant PSEN1. | |
| PSEN1 | |
| AD3/FAD/PS1/S182 | |
| Mouse | |
| 50 μL | |
| Apoptosis | |
| 5663 | |
| Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
| ELISA, Western Blot | |
| Unconjugated | |
| 50% glycerol | |
| BC011729 | |
| PSEN1 | |
| PSEN1 (AAH11729, 280 a.a. ∼ 379 a.a) partial recombinant protein with GST tag. | |
| RUO | |
| Primary | |
| Human | |
| Serum |
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