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Description
The MC813-70 monoclonal antibody reacts with Stage-Specific Embryonic Antigen-4 (SSEA-4), a carbohydrate epitope on the major ganglioside, but not the neutral glycolipid, of human teratocarcinoma cells. As its name implies, the expression of SSEA-4 is stage-specific and can be used to characterize embryonic cells and monitor their differentiation. However, its expression pattern differs in the human and mouse. In the human, SSEA-4 is found on teratocarcinoma (embryonal carcinoma or EC), embryonic inner cell mass (ICM), and embryonic stem (ES) cells, erythrocytes, and the K562 erythromyeloid leukeumia cell line. As human stem cells undergo differentiation, SSEA-4 expression is lost. In the mouse, SSEA-4 is found on oocytes and early cleavage-stage embryos, and primitive ectoderm, but not on EC, ICM, or ES cells. In some cases, SSEA-4 expression appears upon differentiation of mouse EC or ES cells.
Host Species: Mouse
Clone: MC813-70
Isotype: IgG3, κ
Species Reactivity: Human
Immunogen: Human Teratocarcinoma Cell Line
Flow Cytometry
Specifications
| SSEA-4 | |
| Monoclonal | |
| Alexa Fluor 647 | |
| Aqueous buffered solution containing BSA, protein stabilizer, and ≤0.09% sodium azide. | |
| Human Teratocarcinoma Cell Line | |
| 100 Tests | |
| Cell Biology | |
| Human, Mouse | |
| IgG3 κ |
| In vitro Assay | |
| MC813-70 | |
| Stage-Specific Embryonic Antigen-4 | |
| Mouse | |
| Affinity Purified | |
| RUO | |
| Primary | |
| Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze. |
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