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  5. Tocris Bioscience™ Apilimod dimesylate

Tocris Bioscience™ Apilimod dimesylate
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Product Code. 18799956
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25 mg
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18799956 5 mg 5mg
18767466 25 mg 25mg
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Product Code. 18799956 Supplier Tocris Bioscience™ Supplier No. 7283/5

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Description

Potent and selective PIKfyve inhibitor

Apilimod dimesylate is a potent and selective PIKfyve inhibitor (IC50 = 14 nM). Exhibits no significant activity at other lipid kinases and protein kinases, including PIP4K, PIP5K, mTOR, PI3K and PI4K. Inhibits cellular entry by SARS-CoV-2, MERS-CoV and MHV S pseudovirions. Reduces number of SARS-CoV-2-infected hiPSC-derived pneumocyte-like cells by 85% and inhibits SARS-CoV-2 replication in donor lung tissue. Also exhibits selective cytotoxicity in B-cell non-Hodgkin lymphoma compared with normal cells. Inhibits production of IL-12 and IL-23. Anti-inflammatory. Water-soluble.
TRUSTED_SUSTAINABILITY

Specifications

Chemical Name or Material 4-(6-(2-(3-Methylbenzylidene)hydrazinyl)-2-(2-(pyridin-2-yl)ethoxy)pyrimidin-4-yl)morpholine dimethanesulfonate
CAS 870087-36-8
Quantity 5 mg
Target PIKFyve/PIP5K3
Molecular Formula C23H26N6O20.2 CH3SO3H
Purity 0.98
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