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Invitrogen™ APOBEC3G Polyclonal Antibody
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Product Code. 12888262
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Quantity:
100 μg
Unit Size:
100µg
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Product Code. Quantity unitSize
12888262 100 μg 100µg
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Product Code. 12888262 Supplier Invitrogen™ Supplier No. PA520052

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Description

Rabbit Polyclonal Antibody

A suggested positive control is Caco-2 cell lysate. PA5-20052 can be used with blocking peptide PEP-0171.

The Apoliprotein B mRNA-editing, enzyme-catalytic, polypeptide-like (APOBEC) 3 is a multi-isoform member of the cytidine deaminase family of enzymes that act on monomeric nucleoside and nucleotide substrates. Similar to TRIM5-a which targets incoming retroviral capsids, APOBEC3 plays a major role in cellular defense against retroviral infection as at least two isoforms, APOBEC3G and to a lesser extent APOBEC3F, can be incorporated HIV-1 virions and induce hypermutation in the newly synthesized viral DNA and thus destabilize the viral genome. This innate mechanism of retroviral resistance is counteracted by the HIV-1 Vif protein by inducing the ubiquitization and degradation of APOBEC3G; a single amino acid substitution (D128K) blocks APOBEC3G depletion without affecting its inhibitory activity.
TRUSTED_SUSTAINABILITY

Specifications

Antigen APOBEC3G
Applications Immunohistochemistry, Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.02% sodium azide
Gene APOBEC3G
Gene Accession No. Q9HC16
Gene Alias A3G; APOBEC3G; APOBEC-related cytidine deaminase; APOBEC-related protein; APOBEC-related protein 9; apolipoprotein B editing enzyme catalytic polypeptide-like 3G; apolipoprotein B mRNA editing enzyme catalytic polypeptide like 3G; apolipoprotein B mRNA editing enzyme catalytic subunit 3G; apolipoprotein B mRNA editing enzyme cytidine deaminase; apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G; apolipoprotein B mRNA-editing enzyme catalytic polypeptide 3G; ARCD; ARP9; ARP-9; ASGPR2; ASGP-R2; bK150C2.7; CEM15; CEM-15; CLEC4H2; Deoxycytidine deaminase; dJ494G10.1; DNA dC->dU editing enzyme; DNA dC->dU-editing enzyme APOBEC-3G; FLJ12740; HBXBP; HL-2; MDS019; OTTHUMP00000028911; phorbolin-like protein MDS019
Gene Symbols APOBEC3G
Host Species Rabbit
Immunogen A synthetic peptide corresponding to 15 amino acids near the amino-terminus of human APOBEC3G.
Purification Method Antigen Affinity Chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 60489
Target Species Human
Content And Storage Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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