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Invitrogen™ APS Polyclonal Antibody
Rabbit Polyclonal Antibody
Brand: Invitrogen™ PA517608
This item is not returnable.
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Description
It is not recommended to aliquot this antibody. This antibody is not cross-reactive with other adaptor/docking proteins.
APS (adapter protein with Pleckstrin homology and Src homology 2 domains) a member of the Lnk family, is an adaptor protein that is involved in B-cell signaling, insulin signaling, cytoskeletal reorganization. It is tyrosine phosphorylated by JAK2, KIT and other kinases during B-cell receptor stimulation of many different cytokines, chemokines and leukokines. APS has been shown to inhibit the JAK-STAT pathway in collaboration with c-Cbl. It is located in the cytoplasm in pre-PDGF (platelet derived growth factor) stimulated cells and localizes to the plasma membrane and peripheral regions upon PDGF stimulation. This protein is expressed in B-cells and mast cells when detected in haematopoietic cell lines yet is also expressed in many different tissues including spleen, prostrate, testis, uterus, small intestine and skeletal muscle.
Specifications
| APS | |
| Polyclonal | |
| Unconjugated | |
| SH2B2 | |
| adapter protein with pleckstrin homology and Src homology 2 domains; adaptor protein with pleckstrin homology and src homology 2 domains; Alpha-1-antitrypsin; Aps; SH2 and PH domain-containing adapter protein APS; SH2B adapter protein 2; SH2B adaptor protein 2; Sh2b2 | |
| Rabbit | |
| Antigen affinity chromatography | |
| RUO | |
| 10603, 23921 | |
| -20°C | |
| Liquid |
| Immunohistochemistry (Paraffin), Western Blot | |
| 78 μg/mL | |
| 0.01M HEPES with 100 μg/mL BSA, 50% glycerol, 0.15M NaCl and no preservative; pH 7.5 | |
| O14492, Q9JID9 | |
| SH2B2 | |
| Synthetic peptide corresponding to residues near the amino-terminus of human APS. | |
| 100 μL | |
| Primary | |
| Human, Mouse | |
| Antibody | |
| IgG |
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